Monica Andreassen

Stipendiat Monica Andreassen har publisert en ny artikkel.

In the article Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maize, recently published in Food and Agricultural Immunology, BALB/c mice were exposed to purified Cry1Ab proteins and Cry1Ab-containing MON810 plant materials by intranasal installation. No anti-Cry1Ab antibodies were detected following exposure to the plant materials. Exposure to purified Cry1Ab resulted in specific anti-Cry1Ab IgG1 and IgE production, indicating inherent immunogenicity and allergenicity. Mice exposed to leaf extracts from both MON810 and unmodified maize demonstrated influx of lymphocytes and eosinophils in the broncho-alveolar lavage, and increased cytokine release in mediastinal lymph node cells. The results indicate that the airway exposure to Cry1Ab proteins may be a route of practical relevance.

Andreassen, M., Rocca, E., Bøhn, T., Wikmark, O.-G., Van den Berg, J., Løvik, M., Traavik, T. and Nygaard, U. C. (2014). “Humoral and cellular immune responses in mice after airway administration of Bacillus thuringiensis Cry1Ab and MON810 cry1Ab-transgenic maize” Food and Agricultural Immunology DOI:10.1080/09540105.2014.988128