New publication: Genome editing on finfish: Current status and implications for sustainability

07.06.2021


Blix TB, Dalmo RA, Wargelius A, Myhr AI. Genome editing on finfish: Current status and implications for sustainability. Rev Aquacult. 2021;00:1–20. https://doi.org/10.1111/raq.12571

Aquaculture is facing several challenges globally, and the newest solution presented is to use CRISPR and other genome editing tools. These tools allow for knocking out, moderate or knock in genes in organisms. We have systematically reviewed the literature on genome editing of aquaculture finfish globally, resulting in 56 empirical studies. The Nile tilapia is the most studied species, followed by the Atlantic salmon, and China is the country with most studies, followed by the U.S. and Norway. Most of the studies has expressed aquaculture as their objective, while others focus more generally on basic research and fish anatomy and physiology. The most studied traits are reproduction and development, growth, pigmentation, disease resistance, use of trans-GFP, and omega-3 production in the fish. We have identified some technical challenges related to genome editing in finfish, and discuss regulative aspects in the different countries represented. Finally we discuss whether and how the different solutions posed could contribute to sustainable development, and conclude that the respect for biodiversity must be highly prioritized when evaluating new modified organisms.